Transduction of multiple drug resistance of Salmonella enterica serovar typhimurium DT104.
نویسندگان
چکیده
Epidemic strain Salmonella typhimurium DT104 is characterized by various multiresistance patterns. At least some of the resistance genes are organized as integrons. Resistance genes of DT104 isolates can be efficiently transduced by P22-like phage ES18 and by phage PDT17 which is released by all DT104 isolates so far analyzed. Cotransduction tests demonstrate that the resistance genes, although not organized in a unique integron, are tightly clustered on the Salmonella chromosome. The spread of resistance genes in this strain by generalized transduction is discussed.
منابع مشابه
Extended-spectrum β-Lactamase-producing Flora in Healthy Persons
1. Threlfall EJ. Epidemic Salmonella typhimurium DT104 – a truly international epidemic clone. J Antimicrob Chemother. 2000;46:7–10. 2. Lawson AJ, Desai M, O’Brien SJ, Davies RH, Ward LR, Threlfall EJ. Molecular characterisation of an outbreak strain of multiresistant Salmonella enterica serovar Typhimurium DT104 in the UK. Clin Microbiol Infect. 2004;10:143–7. 3. Briggs CE, Fratamico PM. Molec...
متن کاملOccurrence of a Salmonella enterica serovar typhimurium DT104-like antibiotic resistance gene cluster including the floR gene in S. enterica serovar agona.
Recently a chromosomal locus possibly specific for Salmonella enterica serovar Typhimurium DT104 has been reported that contains a multiple antibiotic resistance gene cluster. Evidence is provided that Salmonella enterica serovar Agona strains isolated from poultry harbor a similar gene cluster including the newly described floR gene, conferring cross-resistance to chloramphenicol and florfenicol.
متن کاملMolecular characterization, spread and evolution of multidrug resistance in Salmonella enterica typhimurium DT104.
Multidrug-resistant Salmonella enterica serovar Typhimurium phage type DT104 has emerged during the last decade as a global health problem because of its involvement in diseases in animals and humans. Multidrug-resistant DT104 strains are mostly resistant to ampicillin, chloramphenicol, streptomycin, sulfonamides and tetracyclines (ACSSuT resistance type). The genes coding for such resistances ...
متن کاملAquaculture and Florfenicol Resistance in Salmonella enterica Serovar Typhimurium DT104
To the Editor: In a letter recently published in Emerging Infectious Diseases, Smith (1) discussed evidence that he mistakenly believes to undermine the hypothesis that the fl orfenicol resistance gene present in some isolates of the epidemic Salmonella enterica serovar Typhimurium DT104 strain originated from a fl orfenicol resistance plasmid present in Vibrio damsela (Pasteurella piscicida) t...
متن کاملIdentification of novel Salmonella enterica serovar Typhimurium DT104-specific prophage and nonprophage chromosomal sequences among serovar Typhimurium isolates by genomic subtractive hybridization.
Genomic subtractive hybridization was performed between Salmonella enterica serovar Typhimurium LT2 and DT104 to search for novel Salmonella serovar Typhimurium DT104-specific sequences. The subtraction resulted mainly in the isolation of DNA fragments with sequence similarity to phages. Two fragments identified were associated with possible virulence factors. One fragment was identical to irsA...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- FEMS microbiology letters
دوره 170 1 شماره
صفحات -
تاریخ انتشار 1999